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The first meiotic division of primary spermatocytes produces two haploid secondary spermatocytes, which then undergo a second meiotic division to give rise to four spermatids
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GSH can then be synthesized de novo in a two-step ATP-requiring enzymatic process utilizing glutamate cysteine ligase (GCL) and glutathione synthetase (GS) (Figure 2) [83,87]
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